Aminoadamantanes with Persistent in Vitro Efficacy against H1N1 (2009) Influenza A

Aminoadamantanes with Persistent in Vitro Efficacy against H1N1 (2009) Influenza A

A series of 2-adamantanamines with alkyl adducts of various lengths were examined for efficacy against strains of influenza A including those having an S31N mutation in M2 proton channel that confer resistance to amantadine and rimantadine. The addition of as little as one CH2 group to the methyl adduct of the amantadine/rimantadine analogue, 2-methyl-2-aminoadamantane, led to activity in vitro...

Efficacy of inactivated swine influenza virus vaccines against the 2009 A/H1N1 influenza virus in pigs.

The gene constellation of the 2009 pandemic A/H1N1 virus is a unique combination from swine influenza A viruses (SIV) of North American and Eurasian lineages, but prior to April 2009 had never before been identified in swine or other species. Although its hemagglutinin gene is related to North American H1 SIV, it is unknown if vaccines currently used in U.S. swine would cross-protect against in...

2009 H1N1 Influenza Virus Seroepidemiology

High Titers of Hemagglutination Inhibition Antibodies against 2009 H1N1 Influenza Virus in Southern Iran

Background: Pandemic flu had at least two waves in Iran. Knowing how many of the general population were already exposed to this infection has a major impact on na-tional preventive measures. As of December 30, 2009, a total of 3672 confirmed cases of human infection with a novel Influenza A (2009 H1N1) virus had been reported in Iran with 140 deaths. Objective: In this study we aim to measure,...

Pandemic (H1N1) 2009 influenza.

On 11 June 2009, the World Health Organization declared the first human influenza pandemic since 1968–1969. The responsible virus, pandemic (H1N1) 2009 influenza, is a novel triple-reassortant influenza A virus, incorporating avian, swine and human influenza genes.1 The virus is resistant to the anti-influenza medications, amantadine and rimantadine, but is generally sensitive to the neuraminid...